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Phalloidin - 100µM (500µl)

Cat. #:
5630-01
Shipping:
FedEx Express (Global) FedEx Express (Global) (shipping info)
 Phalloidin
from Amanita phalloides


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Applications

Inhibition of actin depolymerization;
Stabilization of actin filaments.


 

Description
 
Phalloidin binds to actin filaments and inhibits their depolymerization by specific interaction at the interface of adjacent monomers of the filaments. Phalloidin is a bicyclic heptapeptide with high affinity for actin filaments and lower affinity for actin monomers. Binding of Phalloidin leads to a decrease in the rate constant for the dissociation of actin monmers from filament ends. This results in a stabilization of filaments, used in many assays where stable actin filaments are demanded.
Phalloidin is also inhibits the ATP-ase activity of F-actin. Binding arrests actin monomers in a specific G-actin state and stabilizes filament structure by strongly reducing the rate constant for monomer dissociation, an event associated with the trapping of ADP.

Phalloidin binds in 1:1 molar ratio to G-actin, strongly promotes actin polymerization, and stabilizes actin filaments.
 

 
Units

100µM in 500µl (dry component, reconstitute upon arrival)

► 500µl of a 100µM solution stabilize 2mg actin at a 1:1 molar ratio. 





 
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