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Latrunculin A

Cat. #:
5600-01
Shipping:
FedEx Express (EU only) FedEx Express (EU only) (shipping info)
Quantity:
50 µg
Units:
1x
5x ( + 346,00 EUR )

Latrunculin A




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Applications

Cell-permeant natural compound for prevention of actin polymerization, frequently used in in vitro assays


Description

Product name

Latrunculin A (from sea sponge)

Product description

Latrunculin A is a bioactive macrolide derived from sponges that efficiently sequesters G-actin and prevents F-actin assembly. Latrunculin A binds monomeric actin in a 1:1 molar stoichiometry and is frequently used to block actin polymerization in vitro (Kd = 0.2 μM)1.

Overview

Latrunculin A is a cell-permeant macrolide with a 2-thiazolidinone ring. Latrunculin A disrupts actin polymerization due to formation of a 1:1 complex with monomeric G-actin, without affecting the microtubules. Latrunculin A inhibits binding of thymosin β.



Properties

Form

Lyophilized, ready-to-use.

Quantity

50µg, add 100 µl of DMSO to obtain a 1mM stock solution.

Formula

Formal name: (4R)-[(1R,4Z,8E,10Z,12S,15R,17R)-17- hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca- 4,8,10-trien-17-yl]-2-thiazolidinone;

Molecular weight; 421.6 g/mol

Purity

98% HPLC;

Storage instructions

Store at –20°C upon arrival. The product will be stable in performance for at least 1 year from the date of purchase.

Shipping conditions 

At ambient temperature. Upon delivery store at -20°C.

Remarks

For Use in Research only. Not for Use in Human or Veterinary Diagnostical or Therapeutical Applications.

CAS no.

 




References
 

  Actin-latrunculin A structure and function. Differential modulation of actin-binding protein function by latrunculin A.

  Yarmola EG, Somasundaram T, Boring TA, Spector I, Bubb MR.

  J Biol Chem. 2000 Sep 8;275(36):28120-7.



 

 

 
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