Cap Z
CapZ protein, pure. Mw: 66 kDa. Highly pure CapZ actin is an capping protein and a potent actin nucleator.
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Actin dynamics under control.
Capping proteins (CP) are central to the regulation of actin filament dynamics. By blocking the polymerization and depolymerization of actin filaments, they maintain cytoskeletal organization and influence cell shape, motility, and intracellular trafficking.
CapZ specifically caps barbed ends, distinguishing it as a critical tool for dissecting cytoskeletal dynamics.
Actin filament regulation by CapZ apply to both muscle and non-muscle cells, the specific functions and context of CapZ differ, with muscle CapZ tailored for its role in the highly ordered environment of sarcomeres:
Capping Activity: Like non-muscle CapZ, muscle CapZ also binds with high affinity to the barbed ends of actin filaments, preventing polymerization and depolymerization. This regulation is essential in both muscle and non-muscle cells for maintaining actin filament organization.
• Specific Role in Muscle: In muscle cells, CapZ plays a specialized role at the Z-disc of sarcomeres, where it stabilizes the actin filaments necessary for muscle contraction. While non-muscle CapZ is broadly involved in cytoskeletal dynamics, muscle CapZ has a more defined structural role within the sarcomeric architecture.
• Cytoskeletal Organization: The function of blocking actin filament turnover is indeed central to cytoskeletal organization, including in muscle cells, where it ensures proper filament anchoring and alignment within the contractile apparatus.
• Distinguishing Features: Muscle CapZ has isoforms (e.g., α1 and β1 subunits) optimized for the mechanical and structural demands of muscle tissue. These isoforms are adapted to the repetitive contraction cycles and high structural stability required in muscle cells.
Accelerate your cytoskeletal research with the precision and reliability of Non-Muscle CapZ Heterodimer.
Proteins from Hypermol are of validated high biological activity, as described in our publications.
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Non-Muscle and Muscle CapZ Proteins: Actin Filament Regulation
Non-Muscle CapZ Protein
Non-Muscle CapZ is a heterodimeric protein essential for regulating actin filament dynamics in various cellular processes. Comprising α1 (34 kDa) and β2 (32 kDa) subunits, this protein binds with high affinity to the barbed ends of actin filaments in a Ca²⁺-independent manner. By capping the barbed ends, Non-Muscle CapZ prevents both polymerization and depolymerization, maintaining filament stability and precise length control.
Non-Muscle CapZ is a key player in cytoskeletal organization, cell motility, and intracellular trafficking. Its ability to regulate actin filament turnover makes it a critical tool for studying cytoskeletal dynamics in non-muscle cells.
Applications of Non-Muscle CapZ
- In vitro studies of actin filament polymerization and turnover
- Cell biology research on cytoskeletal organization
- Biochemistry and interaction studies with actin-binding proteins
Muscle CapZ Protein
Muscle CapZ plays a specialized role in the structural stability of muscle cells. This heterodimeric protein, composed of α1 and β1 subunits, binds with high affinity to the barbed ends of actin filaments at the Z-disc, where it anchors and stabilizes actin filaments in sarcomeres. By preventing polymerization and depolymerization, Muscle CapZ ensures proper alignment of actin filaments during repetitive contraction cycles.
As a critical regulator of sarcomere dynamics, Muscle CapZ supports the mechanical and structural demands of muscle tissue, making it an essential focus for research on muscle physiology and cytoskeletal integrity.
Applications of Muscle CapZ
- Studies on sarcomere dynamics and muscle contraction
- Research on Z-disc stabilization and actin filament organization
- Investigating the molecular mechanisms of muscle cytoskeleton regulation
Why Choose CapZ Proteins for Your Research?
Both Non-Muscle and Muscle CapZ proteins are invaluable tools for understanding actin filament dynamics. Whether you are studying cytoskeletal organization in non-muscle cells or the structural integrity of sarcomeres in muscle tissue, CapZ proteins provide the precision and reliability needed for advanced research. Contact us today to learn more or place an order.