Cap Z

CapZ
Barbed-end capping
Actin turnover control
66 kDa heterodimer
 
Hypermol CapZ protein
Actin dynamics under control
Highly pure CapZ protein for controlled actin filament barbed-end regulation.
Actin capping protein

CapZ protein for precise control of actin filament dynamics

A purified actin capping protein for barbed-end blocking, filament stabilization and functional cytoskeleton assays.

CapZ is a central regulator of actin filament architecture. By binding with high affinity to the barbed ends of actin filaments, CapZ suppresses both monomer addition and subunit loss at this highly dynamic filament end. This makes CapZ a valuable tool for experiments where actin turnover, filament length, nucleation balance or barbed-end availability must be controlled.

Hypermol® CapZ is suited for biochemical and cell-biological actin research, including studies of actin filament stabilization, sarcomeric Z-disc organization, actin-binding protein function and reconstituted cytoskeleton systems.

Barbed-end control
Blocks actin filament elongation and shortening at the fast-growing filament end.
Filament stabilization
Helps define filament length, reduce turnover and stabilize actin structures in vitro.
Functional assays
Useful for dissecting nucleation, capping activity and actin-binding protein regulation.
Browse CapZ protein
For reconstituted actin systems
CapZ is useful when defined filament-end conditions are required, for example in polymerization assays, motility systems or experiments comparing nucleators and actin-binding proteins.
For muscle cytoskeleton research
In muscle cells, CapZ contributes to actin filament anchoring at the Z-disc and supports the ordered sarcomeric architecture required for contractile function.
For cytoskeletal organization assays
By limiting barbed-end turnover, CapZ helps investigate how actin networks maintain filament alignment, stability, cell shape and intracellular organization.
Typical experimental questions
How does barbed-end capping affect actin polymerization kinetics?
How stable are filaments when dynamic ends are blocked?
How do actin nucleators behave when CapZ competes for filament ends?
How does CapZ influence sarcomeric or cytoskeletal filament organization?
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Proteins from Hypermol® are of validated high biological activity, as described in our publications.
CapZ protein
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CapZ (non-muscle, human recombinant) - 2x50 µg

F-Actin capping and G-actin nucleating protein. Highly specific for barbed ends of actin filaments. Ready-to-use format for diverse experimental workflows. Human recombinant heterodimer with >96% purity. 
 

454,00 EUR
excl. Shipping costs
Cap Z protein
CapZ (non-muscle, human recombinant) - 1.0 mg
F-Actin capping and G-actin nucleating protein. Highly specific for barbed ends of actin filaments. Ready-to-use format for diverse experimental workflows. Human recombinant heterodimer with >96% purity. 
4.187,00 EUR
excl. Shipping costs
CapZ (skeletal muscle, native) - 25 µg
CapZ (skeletal muscle, native) - 25 µg
CapZ is a highly efficient actin capping and actin nucleating protein. It has been purified from rabbit skeletal muscle with >92% purity and shows a very high activity (1:1000 M/M) in fluorometrical assays. 
438,00 EUR
excl. Shipping costs
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Non-Muscle and Muscle CapZ Proteins: Actin Filament Regulation

Non-Muscle CapZ Protein

Non-Muscle CapZ is a heterodimeric protein essential for regulating actin filament dynamics in various cellular processes. Comprising α1 (34 kDa) and β2 (32 kDa) subunits, this protein binds with high affinity to the barbed ends of actin filaments in a Ca²⁺-independent manner. By capping the barbed ends, Non-Muscle CapZ prevents both polymerization and depolymerization, maintaining filament stability and precise length control.

Non-Muscle CapZ is a key player in cytoskeletal organization, cell motility, and intracellular trafficking. Its ability to regulate actin filament turnover makes it a critical tool for studying cytoskeletal dynamics in non-muscle cells.

Applications of Non-Muscle CapZ

  • In vitro studies of actin filament polymerization and turnover
  • Cell biology research on cytoskeletal organization
  • Biochemistry and interaction studies with actin-binding proteins

Muscle CapZ Protein

Muscle CapZ plays a specialized role in the structural stability of muscle cells. This heterodimeric protein, composed of α1 and β1 subunits, binds with high affinity to the barbed ends of actin filaments at the Z-disc, where it anchors and stabilizes actin filaments in sarcomeres. By preventing polymerization and depolymerization, Muscle CapZ ensures proper alignment of actin filaments during repetitive contraction cycles.

As a critical regulator of sarcomere dynamics, Muscle CapZ supports the mechanical and structural demands of muscle tissue, making it an essential focus for research on muscle physiology and cytoskeletal integrity.

Applications of Muscle CapZ

  • Studies on sarcomere dynamics and muscle contraction
  • Research on Z-disc stabilization and actin filament organization
  • Investigating the molecular mechanisms of muscle cytoskeleton regulation

Why Choose CapZ Proteins for Your Research?

Both Non-Muscle and Muscle CapZ proteins are invaluable tools for understanding actin filament dynamics. Whether you are studying cytoskeletal organization in non-muscle cells or the structural integrity of sarcomeres in muscle tissue, CapZ proteins provide the precision and reliability needed for advanced research. Contact us today to learn more or place an order.