Caldesmon

Caldesmon
Thin filament regulator
Actin-myosin-tropomyosin interface
~89 kDa protein
 
Hypermol Caldesmon protein
More than contraction control
Pure Caldesmon for studying thin-filament regulation, actomyosin interaction and cytoskeletal contractility.
Multifunctional thin-filament protein

Caldesmon protein for actomyosin regulation and thin-filament control

A pure multifunctional actin-binding protein for smooth-muscle contractility, actin-myosin regulation and cytoskeletal motility assays.

Caldesmon is a thin-filament-associated regulatory protein positioned at the functional interface between actin, myosin and tropomyosin. It contains binding sites for actin, myosin, tropomyosin and calcium-binding proteins such as calmodulin, making it a valuable tool for dissecting how filament architecture, calcium signaling and phosphorylation control actomyosin activity.

Hypermol® Caldesmon is suited for assays investigating smooth-muscle contraction, actin-activated myosin ATPase regulation, motility, filament bundling and kinase-dependent modulation of cytoskeletal mechanics. It is especially useful when actin filament function must be studied in a more complete regulatory context rather than as isolated actin alone.

Thin-filament control
Integrates actin, myosin and tropomyosin interactions in contractility-focused assays.
Calmodulin-sensitive regulation
Useful for studying calcium/calmodulin-linked modulation of actin filament function.
Motility & ATPase assays
Supports analysis of actin-activated myosin ATPase activity and filament motility.
Browse Caldesmon protein
For smooth-muscle contraction studies
Use Caldesmon to study how thin-filament-associated regulation influences myosin ATPase activation, contractility and actin-based motility.
For regulatory reconstitution
Combine Caldesmon with actin, myosin, tropomyosin and calmodulin to build more physiologically relevant actomyosin regulatory systems.
For phosphorylation workflows
Caldesmon is phosphorylated by several kinases, making it useful for probing kinase-dependent changes in filament regulation and motility.
Strong experimental use cases
Analyze actin-activated myosin ATPase regulation.
Build actin-myosin-tropomyosin-Caldesmon assay systems.
Study calcium/calmodulin-dependent modulation of thin filaments.
Investigate kinase-controlled changes in contractile regulation.
Probe smooth-muscle motility and filament sliding mechanisms.
Compare actin behavior with and without regulatory thin-filament proteins.
Product focus
Pure Caldesmon protein, Mw approximately 89 kDa, for assays investigating actin, myosin, tropomyosin and calcium/calmodulin-linked regulation of thin-filament function.
Hypermol Satisfaction Guarantee
Validated product quality with Satisfaction Guarantee.
Proteins from Hypermol® are of validated high biological activity, as described in our publications.
Caldesmon, native | 2x50 µg
Caldesmon, native | 2x50 µg
Actin filament binding, bundling protein purified from smooth muscle with a purity of >98%. 

 

344,00 EUR
excl. Shipping costs
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