Main page » Proteins » Actin Binding Proteins » Talin

Talin

Focal adhesion scaffold

Integrin-actin linkage

~270 kDa protein

Challenging crosstalks

Pure Talin for studying integrin activation, actin linkage, focal adhesion assembly and mechanosensitive signaling.

Mechanosensitive adhesion linker

Talin protein for integrin-actin linkage and focal adhesion research

Native Talin from smooth muscle for studying adhesion signaling, cytoskeletal anchoring, vinculin recruitment and force-sensitive actin coupling.

Talin is a large multidomain actin-binding protein that connects integrins at the plasma membrane to the actin cytoskeleton. This makes Talin one of the central molecular bridges in focal adhesions, where extracellular matrix attachment, intracellular signaling and mechanical force transmission converge.

Hypermol^® Talin isolated from smooth muscle has an apparent molecular mass of approximately 270 kDa. It consists of an N-terminal head region containing a FERM domain and a large rod domain with binding sites for actin, vinculin and integrins. This architecture makes Talin highly useful for experiments investigating adhesion crosstalk, cytoskeletal mechanics and force-regulated protein interactions.

Integrin activation

Links integrin signaling to cytoskeletal anchoring and adhesion maturation.

Actin linkage

Connects actin filaments with adhesion complexes for force transmission studies.

Vinculin recruitment

Useful for probing talin-vinculin interactions and mechanosensitive adhesion strengthening.

Browse Talin protein

For focal adhesion studies

Use Talin to investigate how integrin engagement is coupled to actin anchoring, adhesion growth and recruitment of structural adhesion proteins.

For mechanobiology

Talin is a key tool for studying force-dependent conformational changes, vinculin-binding site exposure and mechanical reinforcement of adhesions.

For adhesion-cytoskeleton crosstalk

Combine Talin with actin, vinculin, phospholipids, integrin tails or signaling proteins to model adhesion-linked cytoskeletal regulation.

Strong experimental use cases

Study integrin-to-actin linkage in defined biochemical systems.

Analyze talin-vinculin interaction and adhesion reinforcement.

Probe force-sensitive exposure of rod-domain binding sites.

Model focal adhesion assembly and maturation mechanisms.

Investigate phospholipid and signaling-protein crosstalk.

Build adhesion-cytoskeleton reconstitution assays with actin and binding partners.

Product focus

Pure Talin protein isolated from smooth muscle, Mw approximately 270 kDa, supplied as a stable lyophilized and readily soluble protein for assays investigating actin binding, integrin linkage, vinculin interaction and adhesion-associated signaling.

Validated product quality with Satisfaction Guarantee.
Proteins from Hypermol^® are of validated high biological activity, as described in our publications.