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Cofilin

ADF/Cofilin family

Actin severing

18.5 kDa protein

The twisted clue to actin turnover

Pure Cofilin for actin filament severing, depolymerization and cytoskeletal remodeling assays.

Actin turnover regulator

Cofilin protein for actin filament severing and depolymerization

A pure ADF/Cofilin-family protein for controlled actin filament turnover, severing assays and pH-sensitive depolymerization workflows.

Cofilin is a small, ubiquitous actin-binding protein that actively reorganizes the actin cytoskeleton. It binds to G-actin and F-actin, changes the twist and mechanical state of actin filaments, and promotes filament disassembly by severing actin filaments and increasing monomer loss from filament ends.

Hypermol^® Cofilin is suited for biochemical and cell-biological workflows where actin dynamics must be shifted from filament assembly toward turnover. It is especially useful for studying actin filament aging, severing activity, pointed-end depolymerization, actin recycling and cytoskeletal remodeling under defined assay conditions.

Filament severing

Promotes breaks in actin filaments and generates new filament ends for rapid turnover.

Depolymerization control

Supports assays focused on monomer release, filament disassembly and actin recycling.

pH-sensitive dynamics

Useful for studying how pH and buffer conditions modulate actin turnover activity.

Browse Cofilin protein

For actin turnover assays

Use Cofilin to shift actin systems toward disassembly and to quantify how filament severing, end dynamics and monomer recycling affect network remodeling.

For reconstituted cytoskeleton systems

Combine Cofilin with actin, profilin, capping proteins or nucleators to model the balance between filament assembly, branching and disassembly.

For cytoskeletal remodeling research

Cofilin is a key tool for studying cell migration, membrane dynamics and the controlled breakdown of older actin filament networks.

Strong experimental use cases

Measure actin filament severing under defined buffer conditions.

Study pH-sensitive inhibition of G-actin polymerization.

Analyze how Cofilin changes filament twist and mechanical stability.

Compare filament disassembly with and without capping proteins.

Model actin recycling in dynamic cytoskeleton networks.

Investigate migration-related actin remodeling pathways.

Product focus

Pure Cofilin protein, Mw approximately 18.5 kDa, for assays investigating actin depolymerization, filament severing and regulatory control of cytoskeletal actin dynamics.

Validated product quality with Satisfaction Guarantee.
Proteins from Hypermol^® are of validated high biological activity, as described in our publications.