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Profilin

G-actin regulation

ADP/ATP exchange

Human recombinant, untagged

G-actin under control

Pure Profilin for actin monomer handling, nucleotide exchange and controlled filament assembly assays.

Actin monomer gatekeeper

Profilin protein for G-actin regulation and fast actin assembly

Human recombinant, untagged Profilin for actin monomer sequestration, ADP-to-ATP exchange and controlled barbed-end polymerization workflows.

Profilin is a central regulator of the G-actin pool. By binding actin monomers at an actin-actin interaction surface, Profilin prevents spontaneous, uncontrolled polymerization while keeping actin competent for rapid assembly when the correct nucleation or elongation machinery is present.

Profilin also accelerates nucleotide exchange on actin, converting less polymerizable ADP-actin into assembly-ready ATP-actin. This makes Hypermol^® Profilin a useful tool for workflows that require a defined supply of polymerization-competent actin monomers, including formin-, Ena/VASP- and barbed-end-directed actin assembly systems.

G-actin sequestration

Controls the actin monomer pool and limits spontaneous filament formation.

Nucleotide exchange

Promotes conversion of ADP-actin into faster polymerizing ATP-actin.

Directed assembly

Supports controlled barbed-end elongation in reconstituted actin systems.

Browse Profilin protein

For controlled polymerization assays

Use Profilin when actin monomers should be kept soluble but rapidly available for directed filament growth at productive barbed ends.

For reconstituted actin systems

Combine Profilin with actin, formins, Ena/VASP proteins, capping proteins or Arp2/3 systems to tune nucleation, elongation and monomer supply.

For actin homeostasis studies

Profilin is useful for analyzing how cells balance monomer sequestration, nucleotide state, filament assembly and cytoskeletal remodeling.

Strong experimental use cases

Prepare ATP-actin-rich monomer pools for assembly assays.

Control spontaneous G-actin polymerization in vitro.

Study profilin-actin delivery to formin-mediated elongation.

Analyze ADP/ATP exchange on actin monomers.

Compare actin assembly with and without profilin-mediated monomer control.

Build defined actin turnover systems with actin, cofilin and capping proteins.

Product focus

Pure Profilin protein, human recombinant untagged, amino acids 1-140, Mw approximately 15 kDa, supplied as a stable lyophilized protein for assays investigating actin monomer sequestration, nucleotide exchange and controlled filament assembly.

Validated product quality with Satisfaction Guarantee.
Proteins from Hypermol^® are of validated high biological activity, as described in our publications.

Profilin (human recombinant) - 2x50µg

Actin sequestering protein, human recombinant (untagged), AA 1-140, with a purity of >95%. Lyophilized.

from 232,00 EUR

excl. Shipping costs

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