Gelsolin & TL40
Gelsolin
GLN40 / TL40 fragment
Actin severing & capping
Ca²⁺-dependent / Ca²⁺-independent tools
For Ca²⁺-dependent actin regulation
Use full-length Gelsolin when actin severing, barbed-end capping and actin turnover should be coupled to calcium-dependent activation.
For EGTA fragmentation workflows
Use GLN40/TL40 when F-actin must be fragmented under Ca²⁺-free or EGTA-buffered conditions without relying on Ca²⁺ activation.
For actin network remodeling assays
Both tools help define filament length distributions, generate new filament ends and control the architecture of reconstituted actin systems.
Strong experimental use cases
Fragment F-actin into shorter, defined filament populations.
Control barbed-end availability in polymerization assays.
Compare Ca²⁺-dependent Gelsolin with Ca²⁺-independent GLN40/TL40.
Generate seeds or shortened filaments for actin dynamics workflows.
Study severing, capping and nucleation in purified actin systems.
Build actin turnover assays with defined activation conditions.
Product focus
Gelsolin proteins are supplied as natively prepared, highly soluble actin regulatory proteins for Ca²⁺-dependent severing and barbed-end capping. GLN40/TL40 is the N-terminal gelsolin fragment for Ca²⁺-independent F-actin severing and fragmentation assays.
Validated product quality with Satisfaction Guarantee.
Proteins from Hypermol® are of validated high biological activity, as described in our publications.
Proteins from Hypermol® are of validated high biological activity, as described in our publications.
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