Tropomyosin-Troponin

Tropomyosin/Troponin
Thin-filament regulation
Ca²⁺-dependent contraction
Sliding filament model
 
Hypermol Tropomyosin Troponin complex
Regulators of contraction
Pure thin-filament regulatory complex for studying Ca²⁺-controlled actin-myosin interaction in striated muscle systems.
Calcium switch for actomyosin access

Tropomyosin/Troponin complex for regulated muscle thin filaments

A thin-filament regulatory protein complex for Ca²⁺-dependent control of Myosin II interaction with actin in striated muscle models.

The Tropomyosin/Troponin complex controls whether Myosin II can productively interact with actin filaments. Tropomyosin lies along the actin filament, while the troponin subunits sense Ca²⁺, inhibit actomyosin interaction in the relaxed state and transmit the calcium signal into a structural shift that opens the thin filament for contraction.

Hypermol® Tropomyosin/Troponin contains tropomyosin together with Troponin C, Troponin I and Troponin T. It is suited for reconstituted sliding-filament assays, regulated actomyosin ATPase workflows and experiments investigating how calcium signaling controls thin-filament activation in striated muscle systems.

Troponin C
Ca²⁺-sensing subunit that initiates calcium-dependent thin-filament activation.
Troponin I/T
Inhibitory and tropomyosin-binding subunits that couple Ca²⁺ sensing to actomyosin access.
Tropomyosin track
Positions along F-actin to regulate myosin-binding site availability.
Browse Tropomyosin/Troponin complex
For regulated actomyosin assays
Use the complex to study how calcium controls Myosin II access to actin and switches thin filaments between inhibited and activated states.
For sliding-filament models
Combine Tropomyosin/Troponin with actin and fast muscle Myosin II to build striated muscle-inspired contraction and motility systems.
For calcium-response workflows
Ideal for comparing thin-filament behavior under low- and high-Ca²⁺ conditions, including ATPase, motility and binding assays.
Strong experimental use cases
Reconstitute Ca²⁺-regulated thin filaments with actin.
Measure calcium-dependent actin-activated Myosin II ATPase activity.
Study relaxed versus activated thin-filament states.
Model the sliding-filament mechanism in vitro.
Analyze tropomyosin positioning and troponin-mediated regulation.
Build defined striated muscle contractility assays.
Product focus
Pure Tropomyosin/Troponin complex consisting of tropomyosin, Troponin C, Troponin I and Troponin T for assays investigating Ca²⁺-dependent regulation of Myosin II interaction with actin in striated muscle thin filaments.
Hypermol Satisfaction Guarantee
Validated product quality with Satisfaction Guarantee.
Proteins from Hypermol® are of validated high biological activity, as described in our publications.
Tropomyosin-Troponin protein complex
Tropomyosin/Troponin (rabbit skeletal muscle) - 2x100µg
From rabbit skeletal muscle with a purity of ~95%.
  • Instanly soluble;
  • Ready-to-use;
276,00 EUR
excl. Shipping costs
1 to 1 (from a total of 1)