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Vinculin

Focal adhesion protein

F-actin binding tail

116 kDa protein

Key player in actin interactions

Pure Vinculin for studying focal contacts, talin-vinculin coupling, F-actin binding and adhesion reinforcement.

Autoinhibited multiligand adhesion protein

Vinculin protein for focal adhesion reinforcement and F-actin linkage

A pure focal adhesion protein for studying talin-vinculin interaction, actin binding, adhesion maturation and mechanosensitive cytoskeletal coupling.

Vinculin is a single-chain polypeptide with an apparent molecular mass of approximately 116 kDa. It is an autoinhibited multiligand-binding protein of focal contacts and cell-cell adhesion structures, where it helps connect adhesion complexes to the actin cytoskeleton.

Hypermol^® Vinculin contains an F-actin-binding domain in the tail region and is especially useful for experiments investigating focal adhesion strengthening, talin-vinculin coupling, force-sensitive adhesion maturation and the mechanical link between membrane-associated adhesion proteins and actin filaments.

F-actin binding

Tail-domain interaction with actin supports adhesion-to-cytoskeleton linkage studies.

Talin coupling

Useful for probing talin-vinculin interactions and adhesion complex maturation.

Adhesion mechanics

Supports studies of force-sensitive reinforcement of focal contacts and actin anchoring.

Browse Vinculin protein

For focal adhesion research

Use Vinculin to investigate focal contact assembly, adhesion strengthening and the transition from protein recruitment to actin-linked mechanical stabilization.

For Talin-Vinculin workflows

Combine Vinculin with Talin, actin or phospholipid-associated systems to model adhesion crosstalk and force-dependent cytoskeletal anchoring.

For mechanobiology

Vinculin is a key reagent for studying how adhesion proteins reinforce actin linkage under mechanical load and support stable cell-matrix contacts.

Strong experimental use cases

Study Vinculin binding to F-actin in defined biochemical systems.

Analyze Talin-Vinculin coupling in focal adhesion models.

Probe adhesion reinforcement and cytoskeletal anchoring.

Compare inactive and activated adhesion-complex states.

Build reconstituted adhesion-actin linkage assays.

Investigate force-sensitive maturation of focal contacts.

Product focus

Pure Vinculin protein, single-chain polypeptide with Mw approximately 116 kDa, supplied as a stable lyophilized protein and fully functional after reconstitution, for assays investigating F-actin binding, focal contacts and adhesion-cytoskeleton linkage.

Validated product quality with Satisfaction Guarantee.
Proteins from Hypermol^® are of validated high biological activity, as described in our publications.

Vinculin (smooth muscle, turkey) - 100 µg

Vinculin from smooth muscle with a purity of ~98%.

from 295,00 EUR

excl. Shipping costs

Vinculin (smooth muscle, turkey) - 250µg

Vinculin from smooth muscle with a purity of ~98%.

from 739,00 EUR

excl. Shipping costs

Vinculin tail (smooth muscle, turkey) - 50µg

Vinculin tail from natively prepared smooth muscle vinculin is obtained by limited cleavage with protease V8. The C-terminal tail region (851-1066) binds to F-actin and was shown to bundle actin filaments in vitro.

308,00 EUR

excl. Shipping costs