Main page » Proteins » Actin Binding Proteins » Filamin

Filamin

Orthogonal actin networks

Flexible cross-linking

280 kDa homodimer

The secret of flexibility

Pure Filamin for flexible actin cross-linking, orthogonal networks and cytoskeletal mechanics assays.

Flexible actin network cross-linker

Filamin protein for flexible orthogonal actin network formation

A native actin cross-linking protein for building three-dimensional filament networks, gel-like actin structures and mechanobiology-oriented cytoskeleton assays.

Filamin is a large homodimeric actin-binding protein that crosslinks actin filaments into orthogonal, flexible networks. In contrast to tight parallel bundling proteins such as Fascin, Filamin creates open actin meshworks that can resist deformation, distribute mechanical stress and support dynamic cytoskeletal architecture.

Hypermol^® Filamin from turkey gizzard has an apparent molecular mass of approximately 280 kDa and contains an N-terminal actin-binding region followed by repeated rod-like domains. Its hinge regions provide flexibility, making Filamin especially useful for reconstituted actin network mechanics, orthogonal cross-linking assays and studies of cytoskeletal elasticity.

Orthogonal networks

Crosslinks actin filaments into open, three-dimensional network architectures.

Mechanical flexibility

Hinge regions support flexible network formation and stress distribution.

Native protein

Native Filamin from turkey gizzard for actin network reconstitution workflows.

Browse Filamin protein

For actin gelation assays

Use Filamin to generate flexible actin gels and to analyze how cross-link density, filament concentration and ionic conditions shape network stiffness.

For mechanobiology

Filamin is useful for modeling how actin networks absorb, redistribute and resist mechanical stress in cortex-like or scaffold-like systems.

For cross-linker comparison

Compare Filamin-driven orthogonal networks with Fascin-driven parallel bundles or α-actinin-mediated filament cross-linking.

Strong experimental use cases

Build orthogonal actin networks from purified components.

Measure actin gel formation and network elasticity.

Study stress-resistant cytoskeletal architectures.

Compare Filamin, Fascin and α-actinin cross-linking modes.

Analyze flexible scaffold formation in reconstituted systems.

Investigate how actin network geometry affects mechanical behavior.

Product focus

Pure Filamin protein from turkey gizzard, Mw approximately 280 kDa, for assays investigating orthogonal actin cross-linking, flexible network formation and cytoskeletal mechanics.

Validated product quality with Satisfaction Guarantee.
Proteins from Hypermol^® are of validated high biological activity, as described in our publications.