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Thymosin beta-4

Thymosin β4

G-actin sequestration

1:1 actin complex

Small but mighty

Small but mighty

Pure Thymosin β4 for defined G-actin sequestration, monomer pool control and actin assembly workflows.

Actin monomer reservoir protein

Thymosin β4 protein for G-actin sequestration and actin pool control

A small, powerful actin-binding protein for creating defined pools of unpolymerized actin and controlling monomer availability in cytoskeleton assays.

Thymosin β4 binds monomeric actin in a 1:1 complex and keeps G-actin in an unpolymerized reserve state. By buffering the actin monomer pool, this tiny protein helps separate actin availability from immediate filament growth and gives experimental control over when actin can enter polymerization pathways.

Hypermol^® Thymosin β4 is useful for reconstituted actin systems where spontaneous polymerization must be limited, monomer supply must be buffered, or the balance between sequestration and assembly must be studied. It complements Profilin workflows by providing a strong actin-monomer reservoir rather than promoting rapid ATP-actin delivery to elongating barbed ends.

Monomer sequestration

Forms 1:1 complexes with G-actin and limits spontaneous filament assembly.

Actin reservoir

Creates a defined pool of unpolymerized actin available after controlled release.

Assembly control

Helps tune the balance between monomer storage and filament formation.

Browse Thymosin β4 protein

For actin monomer buffering

Use Thymosin β4 to maintain G-actin in a soluble, unpolymerized state and to define how much actin is immediately available for filament growth.

For controlled actin assembly

Combine Thymosin β4 with actin, Profilin, Cofilin, capping proteins or nucleators to tune the transition from monomer storage to filament assembly.

For cytoskeletal homeostasis studies

Thymosin β4 is a useful tool for studying how cells store, release and redistribute actin monomers during cytoskeletal remodeling.

Strong experimental use cases

Create defined G-actin reservoir conditions in vitro.

Suppress spontaneous actin polymerization in monomer pools.

Compare Thymosin β4 sequestration with Profilin-mediated actin delivery.

Study controlled release of actin into assembly pathways.

Build actin homeostasis assays with monomer sequestering and turnover proteins.

Analyze how monomer availability controls filament growth kinetics.

Product focus

Pure Thymosin β4 protein, supplied as a stable lyophilized protein and fully functional after reconstitution, for assays investigating G-actin sequestration, actin monomer pool formation and controlled cytoskeletal assembly.

Validated product quality with Satisfaction Guarantee.
Proteins from Hypermol^® are of validated high biological activity, as described in our publications.

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