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Filamin (smooth muscle, turkey) - 1.0 mg

Cat. #:
8312-02
Shipping:
FedEx Express (Global) FedEx Express (Global) (shipping info)
Quantity:
1.0 mg
Units:
1x
5x ( + 3.984,00 EUR )

 


Filamin
(Actin Binding Protein)


Cat. #: 8312-02  

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 Description

 

 

Protein

Filamin (Filamin A)

Origin

Smooth muscle, turkey

Molecular mass

546kDa

Protein description

Filamin from turkey gizzard is a homodimer (2x273kDa) with a molecular mass of 546kDa, consisting of 24 repeats of ~96 amino acids and an N-terminal actin binding sequence. Filamin crosslinks actin filaments into orthogonal networks.

The C-terminal end of each Filamin monomer is characterized by a hinge region, responsible for the flexibility of actin networks. 

Actin interaction

Actin cross linking protein. Kd actin-binding = 0.5µM.



Properties

 

 

Form

Lyophilized, ready-to-use.

Quantity per unit

1x1.0 mg

Buffer

10mM NaCl, 20mM Tris pH 7.4, 0.5mM DTT and 2.4% disaccharides, when reconstituted with 1.0 ml ultrapure water to obtain a 1mg/ml solution.

Purity

>98% by scanning densitometry from Coomassie G-250 stained SDS-Gels.

Purification notes

Purified from turkey gizzard muscle.

Protein concentration

Determined by OD280 (0.1%=0.64).

Storage instructions

Upon reconstitution the product is stored on ice. This product can also be stored as a glycerol stock at -20°C. Avoid repeated freeze / thaw cycles.

Shipping conditions 

At ambient temperature. Upon delivery store at -70°C.

Remarks

For Use in Research only. Not for Use in Human or Veterinary Diagnostical or Therapeutical Applications. 

CAS no.

 




Further Information


Product DataSheet

Material and Safety Data Sheet

Protein Sequence on NCBI



 

References

Real-time dynamics of emerging actin networks in cell-mimicking compartments.
Deshpande S, Pfohl T.; ​PLoS One. 2015 Mar 18;10(3):e0116521. doi: 10.1371/journal.pone.0116521. eCollection 2015.

 


 

 

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