Actin Binding Proteins

Highly pure, fully functional Actin Binding Proteins...

Actin Binding Proteins (ABPs)

Our quality is your guarantee.
Actin-binding proteins control filament nucleation, barbed-end dynamics, severing, depolymerization, stabilization, cross-linking and force generation. They are essential tools for mechanistic in vitro reconstitution, TIRF single-filament assays, bulk kinetics, co-sedimentation, and structure–function studies.
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Scientific-grade ABPs for quantitative actin research

Actin-binding proteins (ABPs) from Hypermol are quality tested and validated for reliable performance and best results. Use defined ABP activities to tune network architecture and kinetics: branching versus linear growth, filament turnover, bundling/cross-linking, and coupling to adhesion or membrane systems.

Control parameters
Nucleation · Capping · Severing · Turnover
Network mechanics
Bundling · Cross-linking · Stabilization
Coupling modules
Adhesion · Membrane linkage · Regulation
Force generation
Motors (Myosin II / S1 / HMM)

ABP Navigator

Direct links into the current Hypermol ABP portfolio:

Gelsolin Arp 2/3 GST-VCA CapZ alpha-Actinin Fascin Filamin Profilin Thymosin beta-4 Cofilin Tropomyosin Tropomyosin-Troponin Caldesmon Calmodulin Myosin II Myosin S1 HMM Ezrin Vinculin Talin
Functional class Protein / protein fragment
Nucleating proteins
Seed formation and/or initiation of polymer growth.
Gelsolin Arp 2/3 GST-VCA
Bundling proteins
Parallel bundle formation and higher-order organization.
alpha-Actinin Fascin
Capping proteins
Barbed-end blocking to control filament length and dynamics.
CapZ Gelsolin
Cross-linking
Orthogonal networks and mechanical connectivity.
Filamin alpha-Actinin
Actin sequestering proteins
G-actin buffering for defined monomer availability.
Profilin Thymosin beta-4
Actin severing proteins
Controlled filament fragmentation and end generation.
Gelsolin TL40
F-actin depolymerizing proteins
Turnover acceleration and filament disassembly.
Cofilin
F-actin stabilizing proteins
Defined stabilization and protection of filament structure.
Tropomyosin
Regulatory proteins
Modulate actin–myosin interaction and signaling-dependent control.
Tropomyosin-Troponin Caldesmon Calmodulin
Motor proteins
ATP-driven force generation on actin filaments.
Myosin II Myosin S1 HMM
Focal adhesion proteins
Couple actin networks to membranes and adhesion complexes.
Ezrin Vinculin Talin

Proteins from Hypermol are of validated high biological activity, as described in our publications.

Validated product quality with Satisfaction Guarantee!

Products:
Cofilin (non-muscle cofilin) - 1.0mg
Cofilin (non-muscle cofilin) - 1.0mg
F-actin and G-actin binding protein, murine recombinant (untagged), AA 1-166, with a purity of >97%.  
2.455,00 EUR
excl. Shipping costs
Gelsolin (cytoplasmic) - 250 µg
Gelsolin (cytoplasmic) - 250 µg
Actin capping, nucleating and severing protein. Cytoplasmic gelsolin from porcine smooth muscle (> 92% purity).

 

843,00 EUR
excl. Shipping costs
Thymosin beta-4 (human recombinant) - 1.0mg
Thymosin beta-4 (human recombinant) - 1.0mg
Actin sequestering protein, human recombinant (untagged), AA 1-43, with a purity of >98%. Lyophilized.
 
1.248,00 EUR
excl. Shipping costs
Tropomyosin (rabbit skeletal muscle) - 1.0 mg
Tropomyosin (rabbit skeletal muscle) - 1.0 mg
From rabbit skeletal muscle with a purity of ~98%.
  • Ready-to-use;

 

839,00 EUR
excl. Shipping costs
Myosin S1 scheme
Myosin S1 (from rabbit m. psoas) - 2x100µg
Ready-to-use Myosin S1 from rabbit skeletal muscle. Instantly soluble with a purity of ~97%. 
347,00 EUR
excl. Shipping costs
Arp 2/3 protein complex - 1.0 mg (2x500 µg)
Arp 2/3 protein complex - 1.0 mg (2x500 µg)
Pointed end capping and F-actin branching protein, with a strong nucleation upon activation by VCA-domain.    
5.022,00 EUR
excl. Shipping costs
Tropomyosin cardiac muscle
Tropomyosin (cardiac Tropomyosin) - 2x100µg
From porcine cardiac muscle with a purity of ~98%.
  • Instantly soluble;
  • Ready-to-use;

 

268,00 EUR
excl. Shipping costs
Vinculin tail
Vinculin tail (smooth muscle, turkey) - 50µg
Vinculin tail from natively prepared smooth muscle vinculin is obtained by limited cleavage with protease V8. The C-terminal tail region (851-1066) binds to F-actin and was shown to bundle actin filaments in vitro. 
308,00 EUR
excl. Shipping costs
Tropomyosin smooth muscle
Tropomyosin (smooth muscle) - 2x100µg
Native Tropomyosin from smooth muscle with a purity of ~96%.
  • Instantly soluble;
  • Ready-to-use;

 

220,00 EUR
excl. Shipping costs
Heavy meromyosin
Heavy Meromyosin (HMM) - 2x100µg
Ready-to-use Heavy Meromyosin HMM from rabbit skeletal muscle. Instantly soluble with a purity of ~96%. 
388,00 EUR
excl. Shipping costs
NEM-Myosin scheme
NEM-Myosin II (rabbit, m. psoas) - 1x200 µg
Ready-to-use NEM-Myosin from rabbit m. psoas ("fast muscle myosin"), ~98% pure.
 
181,00 EUR
excl. Shipping costs
MotorMix II (for Myosin II ) - 100ml
MotorMix II (for Myosin II ) - 100ml
MotorMix II high ionic-strength buffer kit for soluble myosin II and filament solubilization; includes MotorMix II plus DTT and ATP for fresh supplementation
97,00 EUR
excl. Shipping costs
MotorMix I (for Myosin II filaments) - 100ml
MotorMix I (for Myosin II filaments) - 100ml
Physiological ionic-strength buffer to stabilize myosin II thick filaments and to promote filament assembly from myosin II solutions. DTT and ATP are provided separately and should be added freshly prior to use.
93,00 EUR
excl. Shipping costs
Fascin (human, recombinant) - 1.0 mg
Fascin (human, recombinant) - 1.0 mg
Actin bundling protein, human recombinant (untagged), AA 1-493, with a purity of >99%. 

 

from 2.640,00 EUR
excl. Shipping costs
Alpha-Actinin 4
Alpha-Actinin 4 (non-muscle) - 2x50 µg
Alpha Actinin 4 (non-muscle α-Actinin) has a molecular weight of ~200 kDa and functions as antiparallel homodimer, so that the N-terminal lateral domains can effectively cross-link actin filaments. Purity: ~98%.

 

287,00 EUR
excl. Shipping costs
CapZ (skeletal muscle, native) - 25 µg
CapZ (skeletal muscle, native) - 25 µg
CapZ is a highly efficient actin capping and actin nucleating protein. It has been purified from rabbit skeletal muscle with >92% purity and shows a very high activity (1:1000 M/M) in fluorometrical assays. 
438,00 EUR
excl. Shipping costs
TL 40 mouse recombinant molecule cartoon
Gelsolin TL40 (N-terminal cyt. gelsolin - mouse rec.) - 50 µg
Novel constitutively active fragment of mouse recombinant cytoplasmic Gelsolin for calcium indepenend severing of F-actin, >94% purity.

 

263,00 EUR
excl. Shipping costs
Tropomyosin smooth muscle
Tropomyosin (smooth muscle) - 1 mg
Native Tropomyosin from smooth muscle with a purity of ~96%.
  • Instantly soluble;
  • Ready-to-use;

 

990,00 EUR
excl. Shipping costs
Gelsolin TL40 - GLN40 (N-terminal cytoplasmic gelsolin) - 50 µg
Gelsolin TL40 - GLN40 (N-terminal cytoplasmic gelsolin) - 50 µg
Novel constitutively active fragment TL40 / GLN 40 of the native, cytoplasmic gelsolin protein is used for calcium independent severing of actin filament The gelsolin fragment has a purity of >98%.

 

455,00 EUR
excl. Shipping costs
vca_hwave1
VCA-GST (human recombinant WAVE VCA-domain, GST-tagged) - 250µg
Arp2/3 activating human WAVE VCA-domain (>95% purity).

 

243,00 EUR
excl. Shipping costs
21 to 40 (from a total of 47)